Why the study?
Does the use of total:HDL cholesterol ratio in Framingham-based methods improve the accuracy of identifying high-risk patients for primary prevention of CHD compared to total cholesterol alone or cholesterol thresholds?
Population
126 treated hypertensive men
Comparison
Five CHD risk assessment methods: one based on… vs PROCAM independent risk function predicting CHD…
Design
Cross-sectional
Authors
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Ratio-based methods may improve high-risk identification accuracy; leaves open prospective outcome validation before practice change.
Does the use of total:HDL cholesterol ratio in Framingham-based methods improve the accuracy of identifying high-risk patients for primary prevention of CHD compared to total cholesterol alone or cholesterol thresholds?
Risk assessment methods for primary prevention of CHD should incorporate the total:HDL cholesterol ratio to improve specificity and avoid incorrectly targeting very low-risk patients.
Iftikhar Ul Haq (1999) studied this question.
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