Why the study?
Does oral methyldopa reduce plasma renin activity in human volunteers?
Population
n=5 human volunteers (1 hypertensive and 4 normotensive)
Comparison
Oral methyldopa vs Baseline (before treatment)
Design
Case_series
Authors
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Supports methyldopa's renin-lowering effect beyond BP reduction; hypothesis-generating and should not change practice.
Does oral methyldopa reduce plasma renin activity in human volunteers?
Methyldopa simultaneously decreases mean arterial pressure and plasma renin activity, suggesting a potential causal relationship between these physiological effects.
Mohammed et al. (1969) studied this question.
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