Key result
Beta-blockade reduced the exercise-induced rise in factor VIII:C and VIII:RAg in normal males, which may contribute to the protective effect of these drugs in coronary artery disease.
Why the study?
Does beta-blockade modify exercise-induced changes in haemostatic factors in normal males?
RCT
Double-blind
Does beta-blockade modify exercise-induced changes in haemostatic factors in normal males?
Beta-blockade blunts the exercise-induced rise in factor VIII:C and VIII:RAg, which may contribute to its protective effects in patients with coronary artery disease.
Alterations of platelet function and blood coagulation may occur with exercise or beta-adrenoceptor blockade. To determine if beta-blockade could modify exercise-induced changes in haemostatic factors we performed a double-blind study of acute strenuous exercise in normal males with and without beta-blockade. Exercise increased prostacyclin and plasminogen activator levels but there was no evidence of thrombin generation as indicated by unchanged platelet aggregation responses, beta-thromboglobulin and fibrinopeptide A levels. The only alteration in coagulation by beta-blockade was a reduction in the factor VIII:C and VIII:RAg rise after exercise and this modification may be relevant to the protective effect of these drugs in patients with coronary artery disease.
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Small et al. (2009) conducted an RCT in Healthy. Beta-blockade vs. Without beta-blockade was evaluated on Exercise-induced changes in haemostatic factors. Beta-blockade reduced the exercise-induced rise in factor VIII:C and VIII:RAg in normal males, which may contribute to the protective effect of these drugs in coronary artery disease.
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