Key result
Beta-blocker use at hospital discharge in patients with heart failure and left ventricular systolic dysfunction was associated with a significantly reduced risk of all-cause mortality (HR 0.564).
Why the study?
Does beta-blocker use at discharge improve long-term survival in patients hospitalized for heart failure with left ventricular systolic dysfunction?
Population
947 patients hospitalized with worsening heart failure and left ventricular systolic dysfunction, mean age…
Comparison
Beta-blocker prescribed at hospital discharge. vs No beta-blocker prescribed at hospital discharge.
Design
Cohort
Follow-up
average 2.2 years
Authors
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Supports beta-blocker prescription at discharge in HFrEF; extends observational data but leaves open need for randomized confirmation.
Observational (n=947)
Yes
Does beta-blocker use at discharge improve long-term survival in patients hospitalized for heart failure with left ventricular systolic dysfunction?
Hazard Ratio: 0.564 (95% CI 0.358–0.889)
Absolute Event Rate: 14.5% vs 24.2%
p-value: p=0.014
Prescription of beta-blockers at hospital discharge for patients with heart failure and reduced ejection fraction is associated with a significant long-term survival benefit.
Tsuchihashi‐Makaya et al. (2010) conducted an observational in Heart failure with left ventricular systolic dysfunction (n=947). Beta-blocker use at discharge vs. No beta-blocker use at discharge was evaluated on All-cause mortality (HR 0.564, 95% CI 0.358-0.889, p=0.014). Beta-blocker use at hospital discharge in patients with heart failure and left ventricular systolic dysfunction was associated with a significantly reduced risk of all-cause mortality (HR 0.564).
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