Experimental Hypertension—observations on Sustained Elevation of Systolic and Diastolic Blood Pressure in Dogs

The study of hypertension by animal experi- renal arteries, two have lhad partial nephrectomlly, mentation has been hampered by the absence of and three, ligation of the renal artery. Numerous satisfactory means of producing sustained eleva- observations on systolic and diastolic pressure tions of blood pressure, and by the lack of accu- have been made at appropriate intervals over rate methods of recording systolic and diastolic periods of five to twenty-eight months. Seven blood pressures in the intact unanesthetized ani- additional animals have been subjected to renal mal. ischemia of short duration produced by the ap-Recently, however, Goldblatt and his coworkers plication of Goldblatt clamps. In the prolonged (1) have described an excellent method for the experiments occasional blood nonprotein nitrogen, production of sustained increase in systolic blood twenty-four hour water intake, urinary output, pressure in dogs. Hypertension was produced by and determinations of the specific gravity of the these authors by reducing the blood flow to the urine have served to indicate major changes in kidneys through the application of special silver renal function. clamps to both renal arteries; increases in systolic