Why the study?
Does experimental hypertension produced by renal ischemia cause ophthalmoscopic and pathologic changes in the eyes of dogs and monkeys?
Does experimental hypertension produced by renal ischemia cause ophthalmoscopic and pathologic changes in the eyes of dogs and monkeys?
Experimental hypertension produced by renal ischemia results in observable ophthalmoscopic and microscopic pathologic changes in the eyes of animal models.
Supports hypertensive ocular models in animals; leaves open translation to human retinopathy.
This communication deals with the pathologic changes in the eyes of dogs with persistent elevation of the blood pressure produced by means of renal ischemia. At the time when the first report 1 was made it was known only that permanent elevation of the systolic pressure resulted from this method. This fact has been confirmed by several publications, 2 but recently it was shown 2d,e that there is also an elevation of the diastolic pressure in such animals. This report is restricted to a study of the abnormal changes detected ophthalmoscopically in eight dogs and one monkey with experimental hypertension for varying periods and to the pathologic changes in the eyes of one of these animals (dog 3-8 of the previous report 1 ). This is the only animal so far from which the eyes have been removed during life for a study of the microscopic changes.
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JOHN E. L. KEYES (1937) studied this question.
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