Key result
Permanent partial constriction of the main renal arteries in dogs and monkeys produced persistent hypertension, exhibiting both benign and acute malignant phases similar to human essential hypertension.
Experimental constriction of main renal arteries in dogs and monkeys produces benign and malignant phases of hypertension analogous to essential hypertension in humans.
Establishes renal artery constriction model for hypertension phases; leaves open translation to human essential hypertension therapies.
In healthy dogs and monkeys (macaques) persistent elevation of the systolic and the diastolic pressure, with or without a decrease of renal excretory function, followed permanent partial constriction of the main renal arteries. 1 The eyes of these hypertensive animals have been studied during a period of more than five years. A preliminary report 2 and an interim report 3 have been made. These dogs exhibited two definite types of hypertension: a benign phase, without a decrease of renal excretory function, and an acute malignant phase, with very high blood pressure and severe damage of the renal excretory function. These two phases correspond to the benign and malignant phases of essential hypertension in man. The acute malignant phase of hypertension occurred, or was produced, in dogs already hypertensive, owing to constriction of the main renal arteries when the arteries were reconstricted to a great degree, or in healthy dogs in
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JOHN E. L. KEYES (1938) studied Hypertension. Permanent partial constriction of the main renal arteries was evaluated on Development of hypertension (benign or acute malignant phase). Permanent partial constriction of the main renal arteries in dogs and monkeys produced persistent hypertension, exhibiting both benign and acute malignant phases similar to human essential hypertension.
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