Key result
A high rate pressure product at admission in patients with acute myocardial infarction was associated with lower peak oxygen uptake during hospitalization (17.3 vs. 18.2; p=0.020).
Why the study?
This study aimed to analyze the correlation between rate pressure product at admission and cardiopulmonary function during hospitalization in patients with acute myocardial infarction.
Does high rate pressure product at admission correlate with reduced cardiopulmonary function during hospitalization in patients with acute myocardial infarction?
Observational (n=362)
Does high rate pressure product at admission correlate with reduced cardiopulmonary function during hospitalization in patients with acute myocardial infarction?
A high rate pressure product at admission in patients with acute myocardial infarction is associated with reduced oxygen uptake and worse cardiopulmonary function during hospitalization.
Admission RPP was associated with cardiopulmonary function in AMI; hypothesis-generating and requires prospective validation.
Objective This study aimed to analyze the correlation between the rate pressure product (RPP) and cardiopulmonary function during hospitalization in patients with acute myocardial infarction (AMI).Methods A total of 362 patients with AMI were selected for the study, and the median admission RPP was used as the cutoff point to divide the patients into a low-RPP group (n = 181) and a high-RPP group (n = 181). The relationship between the RPP at admission and the cardiopulmonary function during hospitalization was analyzed.Results The patients in the high-RPP group had a higher body mass index (BMI) (p = 0.014), a higher prevalence of combined hypertension and diabetes mellitus (p < 0.001), a lower incidence of smoking (p = 0.044), and a higher incidence of oscillatory ventilation (6.1% vs. 1.7%, p = 0.029). The differences in RPP at rest, during warm-up, and within 1 and 4 minutes of recovery were statistically significant between the two groups (p < 0.01 on each occasion), while the differences in anaerobic threshold (AT) and watt max (Max) were not statistically significant (p > 0.05 for both). The patients in the low-RPP group had higher oxygen uptake (VO2 [AT]: 14.9 ± 3.4 vs. 14.2 ± 3.6, p = 0.048) and (VO2peak [Max]:18.2 ± 3.8 vs. 17.3 ± 3.8, p = 0.020). The RPP at admission was negatively correlated with VO2 (AT) and VO2peak (p < 0.05) using the regression Equation VO2peak = 33.682 + (−0.012 * RPP at admission/100) + (−0.105 * Age) + (−0.350 * BMI), while there was no correlation between the RPP at admission and VO2 (AT) (p = 0.149).Conclusion The RPP at admission was negatively correlated with cardiopulmonary function during hospitalization in patients with AMI. Patients with a high RPP were more likely to have a combination of obesity, hypertension, diabetes mellitus, and reduced oxygen uptake during exercise, while a high RPP at admission appeared to affect their cardiovascular response indicators during exercise.
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Zeng et al. (2023) conducted an observational in acute myocardial infarction (n=362). High rate pressure product (RPP) at admission vs. Low rate pressure product (RPP) at admission was evaluated on Peak oxygen uptake (VO2peak [Max]) (p=0.020). A high rate pressure product at admission in patients with acute myocardial infarction was associated with lower peak oxygen uptake during hospitalization (17.3 vs. 18.2; p=0.020).
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