Key result
A peak VO2 <12 ml/kg/min predicted cardiovascular death and urgent heart transplantation in heart failure patients with eGFR ≥60 (HR 1.75), but offered limited prognostic accuracy (AUC 0.57) in those with eGFR <45.
Population
2,938 patients with chronic systolic heart failure who underwent clinical, laboratory, echocardiographic and…
Design
Cohort
Follow-up
mean 3.7 years
Authors
Loading...
Peak VO2 <12 ml/kg/min warrants caution for prognosis in HF with eGFR <45; supports eGFR-stratified validation of CPET thresholds.
Cohort (n=2,938)
Yes
Hazard Ratio: 1.75 (95% CI 1.06–2.91)
p-value: p=0.0292
In patients with systolic heart failure, renal dysfunction correlates with peak VO2, and a standard peak VO2 cutoff of 12 ml/kg/min offers limited prognostic information in those with more severely impaired renal function.
Scrutinio et al. (2015) conducted a cohort in Chronic Heart Failure with Reduced Left Ventricular Ejection Fraction (n=2,938). Peak exercise oxygen consumption (VO2) <12 ml/kg/min vs. Peak VO2 ≥12 ml/kg/min was evaluated on Composite of cardiovascular death and urgent heart transplantation at 3 years (HR 1.75, 95% CI 1.06-2.91, p=0.0292). A peak VO2 <12 ml/kg/min predicted cardiovascular death and urgent heart transplantation in heart failure patients with eGFR ≥60 (HR 1.75), but offered limited prognostic accuracy (AUC 0.57) in those with eGFR <45.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: