Decreased Heterogeneity of Capillary Plasma Flow in the Rat Whisker-Barrel Cortex during Functional Hyperemia

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Why the study?

Does functional activation decrease microcirculatory flow heterogeneity in the rat brain?

Structured PICO

Does functional activation decrease microcirculatory flow heterogeneity in the rat brain?

Population

Rats (model for functional hyperemia in the whisker-barrel cortex)

Intervention

Deflection of the right mystacial vibrissae for 2 min at frequencies of 1-7 Hz

Comparator

Right side (unstimulated) or different stimulation frequencies

Outcome

Capillary plasma perfusion heterogeneity (coefficient of variation of Evans blue concentrations) and cerebral blood flow (CBF)surrogate

Functional hyperemia in the brain is associated with a reciprocal decrease in microcirculatory flow heterogeneity.

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Functional hyperemia may reduce microcirculatory heterogeneity in rat cortex; leaves open translation to human neurovascular coupling.

Vogel et al. (1996) studied this question.

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