Key result
Cardiopulmonary bypass did not significantly alter platelet mitochondrial respiration (mean difference -0.02; 95% CI -1.45 to 1.42; p=0.98) and did not correlate with aggregation or bleeding.
Why the study?
Does cardiopulmonary bypass affect platelet mitochondrial respiration and correlate with aggregation and bleeding in adult cardiac surgery patients?
Observational (n=18)
Does cardiopulmonary bypass affect platelet mitochondrial respiration and correlate with aggregation and bleeding in adult cardiac surgery patients?
Platelet mitochondrial respiration is preserved after cardiopulmonary bypass and does not correlate with aggregation or bleeding.
Answers are grounded in this paper and cite their sources.
Does not implicate mitochondrial respiration in CPB bleeding; leaves open alternative mechanisms for larger validation.
BACKGROUND: Cardiopulmonary bypass (CPB) may cause platelet dysfunction, contributing to bleeding. There are no investigations of how CPB affects platelet mitochondrial respiration and what correlation this has with platelet aggregation and bleeding. METHODS: We studied platelet mitochondrial respiration and aggregation in eighteen adult cardiac surgery patients having CPB. The relationships between respiration, aggregation and postoperative bleeding were analyzed. RESULTS: Platelet respiration, reflected by the respiratory control ratio (RCR), was unchanged after CPB (mean difference in RCR= -0.02 (95% CI=-1.45 to 1.42), p=0.98). Further, there were no significant relationships between indexed adenosine diphosphate (ADP) or thrombin receptor-activating peptide (TRAP)-induced aggregation and the RCR (p=0.12 and p=0.41). Only post-CPB ADP - induced aggregation correlated with 24-hr chest tube output (p=0.04), but indexing for platelet count attenuated the effect (p=0.07). CONCLUSION: Platelet mitochondrial respiration is preserved after CPB and is not correlated with aggregation or bleeding. Only post-CPB, ADP-induced aggregation correlates with postoperative bleeding.
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Mazzeffi et al. (2016) conducted an observational in Cardiac surgery requiring cardiopulmonary bypass (n=18). Cardiopulmonary bypass vs. Pre-cardiopulmonary bypass baseline was evaluated on Platelet mitochondrial respiration (respiratory control ratio) (MD -0.02, 95% CI -1.45 to 1.42, p=0.98). Cardiopulmonary bypass did not significantly alter platelet mitochondrial respiration (mean difference -0.02; 95% CI -1.45 to 1.42; p=0.98) and did not correlate with aggregation or bleeding.
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