Why the study?
Cardiopulmonary bypass is associated with platelet dysfunction, an important cause of postoperative bleeding whose etiology is not completely understood.
Does protamine administration after cardiopulmonary bypass cause platelet dysfunction?
Design
Small-group study
Authors
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Protamine may contribute to post-CPB platelet dysfunction; leaves open whether targeted reversal improves outcomes in cardiac surgery.
Does protamine administration after cardiopulmonary bypass cause platelet dysfunction?
Protamine administration after cardiopulmonary bypass appears to play a central mechanistic role in postoperative platelet dysfunction and count decrease.
Epstein et al. (2021) studied this question.
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