Key result
Pulsatile conditioning in a single-use bioreactor for 72 hours improved human mesenchymal stem cell infiltration into decellularized ovine aortic valves, retaining MSC-valve interstitial phenotype.
Why the study?
Does pulsatile conditioning in a single-use bioreactor improve cellular infiltration in decellularized ovine aortic valves seeded with hMSCs?
Population
Decellularized ovine aortic valves seeded with human mesenchymal stem cells (hMSC)
Design
Preclinical
Follow-up
72 hours
Authors
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May advance ex vivo recellularization protocols; leaves open in vivo durability and clinical translation.
Does pulsatile conditioning in a single-use bioreactor improve cellular infiltration in decellularized ovine aortic valves seeded with hMSCs?
A novel single-use bioreactor using pulsatile conditioning improves hMSC infiltration into decellularized ovine aortic valves, representing a step toward clinical translation of tissue-engineered heart valves.
Converse et al. (2015) studied Congenital heart disorders. Pulsatile conditioning in a single-use bioreactor was evaluated on Cellular infiltration into the interstitium of the leaflet. Pulsatile conditioning in a single-use bioreactor for 72 hours improved human mesenchymal stem cell infiltration into decellularized ovine aortic valves, retaining MSC-valve interstitial phenotype.