Key result
Seeding autologous ovine cells onto a biodegradable scaffold using a medium containing collagen resulted in the highest seeding efficiency and largest cell population compared to other methods.
Population
Myofibroblasts and endothelial cells isolated from an ovine artery, seeded on a synthetic biodegradable…
Comparison
Seeding of myofibroblasts using a medium… vs Daily seeding of myofibroblasts for 10 days plus…
Design
Preclinical
Follow-up
14 days
Authors
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May enhance scaffold seeding in ovine models; leaves open translation to human tissue-engineered valves.
Using a collagen-containing medium improves the seeding efficiency of autologous cells on biodegradable scaffolds for tissue-engineered heart valves.
Kim et al. (2000) studied Tissue-engineered heart valves. Seeding myofibroblasts with medium containing collagen vs. Daily seeding or single seeding with simple medium was evaluated on Seeding efficiency. Seeding autologous ovine cells onto a biodegradable scaffold using a medium containing collagen resulted in the highest seeding efficiency and largest cell population compared to other methods.
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