Population
Porcine heart valve cells (myofibroblasts and endothelial cells) seeded on a type I collagen scaffold
Comparison
Tissue engineering of heart valve-like tissue vs Normal native heart valves
Design
Preclinical
Authors
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Supports preclinical scaffold engineering; leaves open whether structural resemblance predicts in vivo durability or hemodynamics.
Tissue engineered heart valves using porcine cells on a collagen scaffold demonstrate cellular and extracellular matrix organization that strongly resembles native valve tissue.
Rothenburger et al. (2002) studied this question.
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