September 1, 2001Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Characterization of a Mouse Model for Thrombomodulin Deficiency

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Population

Inbred C57BL/6J TM(Pro/Pro) mice and 129SvPas mice

Comparison

TM mutation and exposure to… vs Normal (wild-type) mice

Design

Preclinical

Authors

HWHartmut WeilerMedical College of Wisconsin VLVolkhard LindnerMaineHealth BKBryce A. KerlinNationwide Children's Hospital

Discussion

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Implication

Animal data preclude practice change; leaves open whether thrombomodulin variants modulate human thrombosis or sepsis risk.

Structured PICO

Population

Inbred C57BL/6J TM(Pro/Pro) mice and 129SvPas mice

Intervention

TM(Pro/Pro) mutation (disrupting TM-dependent activation of protein C) and exposure to thrombotic/inflammatory stimuli (FeCl3-induced acute endothelial injury, permanent ligation of the carotid artery, endotoxin)

Comparator

Normal (wild-type) mice

Outcome

Thrombosis susceptibility (platelet thrombus growth, vascular stasis-induced thrombosis) and sepsis response (mortality, cytokine production)surrogate

Thrombomodulin deficiency in mice causes a hypercoagulable state and increased susceptibility to thrombosis and sepsis, which is modulated by genetic background.

Cite This Study

Weiler et al. (2001) studied this question.

synapsesocial.com/papers/6a75cbc03c1d3f13c2dd9ebb https://doi.org/10.1161/hq0901.094496

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Characterization of a Mouse Model for Thrombomodulin Deficiency

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of a Mouse Model for Thrombomodulin Deficiency

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider