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July 19, 2004Journal of the American Geriatrics Society

Risk Factors for Deep Vein Thrombosis in Inpatients Aged 65 and Older: A Case‐Control Multicenter Study

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Why the study?

What are the independent risk factors for symptomatic deep vein thrombosis in hospitalized patients aged 65 and older?

Population

620 geriatric inpatients aged 65 and older across 19 geriatric departments.

Design

Case-control

Follow-up

16 months

Authors

SWSébastien Weill‐EngererSorbonne UniversitéSMSylvie MeaumeSorbonne UniversitéALAmina LahlouUniversité Claude Bernard Lyon 1

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Overview

Hypothesis-generating for DVT risk stratification in geriatric inpatients; prospective validation required before clinical use.

Key Points

  • To identify independent clinical risk factors for symptomatic deep vein thrombosis in geriatric inpatients and define high-risk patients who would benefit from preventive therapy.
  • Conducted a prospective, multicenter hospital-based case-control study across 19 geriatric departments over a 16-month surveillance period.
  • Evaluated 23 potential risk factors and compared 310 consecutive inpatients aged 65 and older with symptomatic deep vein thrombosis against 310 randomly selected controls using multivariate logistic regression.
  • Developed a clinical risk score based on the sum of the odds ratios of the identified independent predictors.
  • Six independent risk factors emerged: mobility restriction (OR = 1.73 for limited mobility; OR = 5.64 for bedridden <15 days), age ≥75 years (OR = 1.5 per 10-year increase), history of deep vein thrombosis or pulmonary embolism (OR = 3.38), acute heart failure (OR = 2.52), chronic lower-limb edema (OR = 2.51), and lower-limb paresis or paralysis (OR = 2.06).
  • A cumulative risk score of 8 or higher corresponded to an 88.7% probability of having symptomatic deep vein thrombosis.

Structured PICO

What are the independent risk factors for symptomatic deep vein thrombosis in hospitalized patients aged 65 and older?

P
Population
620 geriatric inpatients aged 65 and older (310 consecutive patients with symptomatic DVT and 310 randomly selected controls) across 19 geriatric departments.
O
Outcome
Development of symptomatic deep vein thrombosis (DVT)hard clinical

Identifies six key clinical risk factors for symptomatic DVT in geriatric inpatients, allowing for the creation of a predictive score to guide targeted preventive treatment.

Cite This Study

Weill‐Engerer et al. (2004) studied this question.

synapsesocial.com/papers/6a75cd1c117c5bc884dd7eddhttps://doi.org/10.1111/j.1532-5415.2004.52359.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systematic Lung Scans Reveal a High Frequency of Silent Pulmonary Embolism in Patients With Proximal Deep Venous Thrombosis2000 · 247 citations
  2. 2Risk Factors for Deep Vein Thrombosis and Pulmonary Embolism2000 · 2,186 citations
  3. 3Prevalence and Prevention of Deep Venous Thrombosis of the Lower Extremities in High-Risk Pulmonary Patients1988 · 69 citations
  4. 4Trends in the Incidence of Deep Vein Thrombosis and Pulmonary Embolism1998 · 2,680 citations
  5. 5Acquired Risk Factors for Deep-Vein Thrombosis in Symptomatic Outpatients1994 · 178 citations