Key result
Quantitative RV SPECT imaging detected perfusion abnormalities significantly more frequently in patients with ARVC (65.6%) than in those with idiopathic RVT (4.4%) or controls (0.6%) (P=0.0001).
Why the study?
Does quantitative analysis of RV SPECT imaging with (99m)Tc-tetrofosmin/sestamibi differentiate ARVC from idiopathic RVT and controls?
Observational (n=57)
Does quantitative analysis of RV SPECT imaging with (99m)Tc-tetrofosmin/sestamibi differentiate ARVC from idiopathic RVT and controls?
Non-invasive RV perfusion mapping using a (99m)Tc-labelled tracer is useful for the quantitative evaluation of RV substrates and differentiating ARVC from idiopathic RVT.
Answers are grounded in this paper and cite their sources.
RV SPECT perfusion mapping may differentiate ARVC from idiopathic RVT; leaves open diagnostic adoption pending prospective validation.
The identification of right ventricular (RV) abnormalities is clinically important in the evaluation of arrhythmogenic substrates in right ventricular-originated ventricular tachycardia (RVT). The purpose of this study was to determine the diagnostic benefit of quantitative analysis in RV single photon emission computed tomography (SPECT) imaging with (99m)Tc-tetrofosmin/sestamibi in patients with RVT. Thirty patients with RVT (15 with idiopathic RVT and 15 with arrhythmogenic right ventricular cardiomyopathy (ARVC)) were compared with 27 control subjects (including 11 with right bundle branch block) with regard to the semiquantitative RV uptake score in each of six segments and the quantitative RV extent score in polar coordinate map displays by SPECT imaging. The RV total score and RV extent score were compared with the RV global function. Perfusion abnormalities were more frequently detected (P = 0.0001) in the ARVC group (59/90, 65.6%) than in the idiopathic RVT group (4/90, 4.4%) or controls (1/162, 0.6%). The RV extent score in the ARVC group (53.0 +/- 24.8) was significantly higher than that in the idiopathic RVT group (8.4 +/- 10.1) or controls (1.2 +/- 4.9). The RV extent score correlated well with the regional RV perfusion score (P < 0.0001) and with the RV ejection fraction (P < 0.0001). Non-invasive RV perfusion mapping using a (99m)Tc-labelled tracer is useful for the quantitative evaluation of RV substrates in patients with ARVC.
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EGUCHI et al. (2002) conducted an observational in Right ventricular-originated ventricular tachycardia (RVT) (n=57). Quantitative RV SPECT imaging with (99m)Tc-tetrofosmin/sestamibi vs. Idiopathic RVT and controls was evaluated on Detection of perfusion abnormalities (per segment) (p=0.0001). Quantitative RV SPECT imaging detected perfusion abnormalities significantly more frequently in patients with ARVC (65.6%) than in those with idiopathic RVT (4.4%) or controls (0.6%) (P=0.0001).
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