Assessment of right ventricular sympathetic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy: An 123I-metaiodobenzylguanidine SPECT/CT study

Figures

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  Figure 1. Hybrid SPECT/CT fusion scan. Representative image for VOI definition for the right (yellow) and left (green) ventricle as well as the mediastinum (blue) in transverse (A) and coronal (B) planes

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  Figure 2. Representative planar and tomographic images of cases with normal (left) and reduced (right) 123I-MIBG uptake. Normal (left; IVF group, H/M ratio = 1.87, LV/M ratio = 3.76, RV/M ratio = 2.01) and reduced (right; ARVC/D group, H/M ratio = 1.12, LV/M ratio = 1.79, RV/M ratio = 1.34) uptake as planar (top) and SPECT/CT image (bottom)

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  Figure 3. Ventricle-to-mediastinum ratios in the IVF and the ARVC/D group. The LV/M ratio (3.9 ± 0.8 vs. 3.2 ± 0.5) as well as the RV/M ratio (2.0 ± 0.2 vs. 1.6 ± 0.3) was significantly higher in the IVF group as compared to the ARVC/D group. (ARVC/D, arrhythmogenic right ventricular cardiomyopathy / dysplasia; IVF, idiopathic ventricular fibrillation; LV/M ratio, left ventricle-to-mediastinum ratio; RV/M ratio, right ventricle-to-mediastinum ratio)

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  Figure 4. ROC analysis for planar, as well as SPECT/CT based analysis. Optimal cut-off values were 1.66 for the planar H/M ratio (75% sensitivity, 60% specificity; (A), 3.41 for the LV/M ratio (77% sensitivity, 80% specificity; (B), and 1.86 for the RV/M ratio (88% sensitivity, 90% specificity; (C). (AUC, area under the curve)