Key result
In a 53-year-old man with Brugada syndrome, the use of multiple antihistamines and antiallergenic drugs markedly enhanced coved-type ST-segment elevations, which regressed upon discontinuation.
Why the study?
Do antihistamines and antiallergenic drugs enhance Brugada-type ST-segment changes in patients with Brugada syndrome?
Case Report (n=1)
No
Do antihistamines and antiallergenic drugs enhance Brugada-type ST-segment changes in patients with Brugada syndrome?
Antihistamines and antiallergenic drugs may enhance Brugada-type ST-segment changes, suggesting that special caution is needed when prescribing these medications to patients with Brugada syndrome.
Antihistamines may enhance Brugada-type ST elevations; hypothesis-generating case observation requiring prospective confirmation before any practice implications.
We describe a case of Brugada syndrome, in which a coved type ST-segment elevation was enhanced by antihistamines and antiallergenic drugs. The patient had been treated with four kinds of antihistamines and antiallergenic drugs. The twelve-lead ECG exhibited a coved type ST-segment elevation in leads V(1) and V(2), and their enhancement was induced by pilsicainide. After discontinuing those drugs, the ST segment elevation in leads V(1) and V(2) became reduced. An ICD implantation was selected for the therapy since ventricular fibrillation was induced. Our report discusses the possible contribution of antihistamines and antiallergenic drugs to the Brugada type ST-segment changes.
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Matsuki et al. (2009) conducted a case report in Brugada syndrome (n=1). Antihistamines and antiallergenic drugs vs. Discontinuation of drugs was evaluated on ST-segment elevation in leads V1 and V2. In a 53-year-old man with Brugada syndrome, the use of multiple antihistamines and antiallergenic drugs markedly enhanced coved-type ST-segment elevations, which regressed upon discontinuation.
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