Key result
Age was an independent risk factor for postoperative deep vein thrombosis in patients with lower extremity fractures receiving anticoagulation (OR 1.04; 95% CI 1.03-1.05; P=.000).
Why the study?
The study aimed to investigate deep vein thrombosis in patients with lower extremity fractures who received anticoagulation treatment in the perioperative stage.
Observational (n=404)
Odds Ratio: 1.04 (95% CI 1.03–1.05)
p-value: p=.000
Despite perioperative anticoagulation, patients with lower extremity fractures have a high incidence of DVT that peaks postoperatively, with age being a consistent independent risk factor.
Supports age-stratified DVT vigilance in anticoagulated fracture patients; leaves open need for targeted prophylaxis trials.
This study aimed to investigate deep vein thrombosis (DVT) in patients with lower extremity fractures who received anticoagulation treatment in the perioperative stage. We collected the patients’ clinical data and diagnosed DVT using Doppler ultrasonography. Preoperative, postoperative, and 1-month postoperative examinations were performed. The patients were divided into thrombosis and non-thrombosis groups according to ultrasonographic findings. A total of 404 patients were included in the study. The preoperative, postoperative, and 1-month postoperative incidence rates were, respectively, 35%, 55%, and 40% for DVT and 12%, 22%, and 20% for DVT in the uninjured contralateral lower extremity. The incidence of perioperative DVT decreased over time from 223 (55%) to 161 (40%). Multivariate analysis revealed that the independent risk factors for preoperative that of DVT were age (odds ratio [OR]: 1.03; 95% CI: 1.01-1.04; P = .000); postoperative that of DVT were age (OR: 1.04; 95% CI: 1.03-1.05; P = .000), blood loss (OR: 1.001; 95% CI: 1.000-1.002; P = .018), and American Society of Anesthesiologists classification (OR: 2.07; 95% CI: 1.16-3.72; P = .014); and 1-month postoperative that of DVT were age (OR: 1.05; 95% CI: 1.03-1.07; P = .000), respectively. In conclusion, the incidence of perioperative DVT decreased over time in patients who received anticoagulation treatment. Age was an important risk factor for perioperative DVT.
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Zhang et al. (2020) conducted an observational in Lower extremity fractures (n=404). Age was evaluated on Postoperative deep vein thrombosis (OR 1.04, 95% CI 1.03-1.05, p=.000). Age was an independent risk factor for postoperative deep vein thrombosis in patients with lower extremity fractures receiving anticoagulation (OR 1.04; 95% CI 1.03-1.05; P=.000).
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