December 1, 1989Development

Neural control of the sequence of expression of myosin heavy chain isoforms in foetal mammalian muscles

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Population

Foetal and neonatal rats (calf muscles)

Comparison

Chronic paralysis or denervation initiated at… vs Normal development (controls)

Design

Preclinical

Authors

AHAJ HarrisJohn Innes Centre RFRobin B. FitzsimonsLetterkenny University Hospital JMJohn C. McEwanAgResearch

Discussion

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Implication

Identifies activity-dependent fiber specification window in rodents; leaves open translation to human fetal myogenesis or interventions.

Structured PICO

Population

Foetal and neonatal rats (calf muscles)

Intervention

Chronic paralysis or denervation initiated at different embryonic stages (E15 or earlier, later than E15, or transient paralysis on E15)

Comparator

Normal development (controls)

Outcome

Expression sequence of slow, embryonic, and neonatal myosin heavy chain (MHC) isoforms in primary myotubessurrogate

Active innervation during a critical embryonic period (E15-17) is required for the normal sequence of myosin heavy chain isoform expression and differentiation of slow muscle fibers in rats.

Cite This Study

Harris et al. (1989) studied this question.

synapsesocial.com/papers/6a75d2ba87be37a05b16245e https://doi.org/10.1242/dev.107.4.751

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Neural control of the sequence of expression of myosin heavy chain isoforms in foetal mammalian muscles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Neural control of the sequence of expression of myosin heavy chain isoforms in foetal mammalian muscles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider