Evidence for myoblast-extrinsic regulation of slow myosin heavy chain expression during muscle fiber formation in embryonic development.
Population
Human myoblast clones derived from muscle tissues at six stages of human development.
Design
Preclinical
Authors
Discussion
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Implication
Indicates extrinsic control of slow MyHC in myoblasts; leaves open niche-targeted approaches in muscle regeneration models.
Structured PICO
P
Population
Human myoblast clones (n = 2,119) derived from muscle tissues at six stages of human development (weeks 7, 9, 16, and 22 of gestation, 2 months after birth, and adult).
I
Intervention
Differentiation in tissue culture (including up to 25 population doublings).
O
Outcome
Expression of slow myosin heavy chain (MyHC) upon differentiation.surrogate
The expression of slow myosin heavy chain during human embryonic development is largely determined by environmental factors rather than commitment to a distinct myoblast lineage.
Cite This Study
Cho et al. (1993) studied this question.