Population
Dogs (normal and with pulmonary-artery stenosis)
Comparison
Acute imposition of pulmonary-artery stenosis vs Normal dogs and internal control (left ventricle)
Design
Preclinical
Follow-up
24 days
Authors
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Indicates early protein synthesis surge in acute RV hypertrophy; hypothesis-generating in canine model, requires human validation before clinical consideration.
Acute pulmonary-artery stenosis in dogs induces rapid right-ventricular hypertrophy driven by a significant early increase in protein synthesis rates.
Everett et al. (1977) studied this question.
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