Evidence for an Indirect Sympathetic Control of Atrial Stretch Receptor Discharge in the Dog
Population
Anesthetized, open-chest dogs
Comparison
Left stellate ganglion stimulation following… vs Withdrawal of blood in steps following…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Clarifies indirect sympathetic control of atrial receptors in animals; leaves open direct effects and clinical translation.
Structured PICO
P
Population
Anesthetized, open-chest dogs
I
Intervention
Left stellate ganglion stimulation following volume expansion
C
Comparator
Withdrawal of blood in steps following intravascular volume expansion (hemorrhage)
O
Outcome
Discharge rate of atrial type B stretch receptors and left atrial pressuresurrogate
Sympathetic stimulation decreases atrial stretch receptor discharge indirectly by reducing left atrial pressure, rather than through a direct effect on the receptors.
Cite This Study
Zucker et al. (1974) studied this question.