January 1, 2001Journal of Cardiovascular Electrophysiology

Species Plays an Important Role in Drug‐Induced Prolongation of Action Potential Duration and Early Afterdepolarizations in Isolated Purkinje Fibers

View Full Paper

Ask AI

Bookmark

Population

Isolated Purkinje fibers from hearts of rabbits, guinea pigs, dogs, swine, goats, or sheep

Design

Preclinical

Follow-up

25 minutes

Authors

HLHua Rong LuElectrophysiology RMROGER MARIËNJanssen (Belgium)ASANN SAELSJanssen (Belgium)

Discussion

Member takes

Implication

Rabbit Purkinje fibers may be the preferred in vitro model for detecting drug-induced APD prolongation; leaves open translation to human proarrhythmia risk.

Structured PICO

Population

Isolated Purkinje fibers (n = 7 to 11 per species) from hearts of rabbits, guinea pigs, dogs, swine, goats, or sheep

Intervention

Superperfusion in Tyrode's solution with dofetilide (1 x 10(-8) M) or quinidine (1 x 10(-5) M) for 25 minutes, stimulated at 1 Hz for 20 minutes and at 0.2 Hz for 5 minutes

Outcome

Prolongation of action potential duration at 90% repolarization (APD90) and induction of early afterdepolarizations (EADs)surrogate

Rabbit Purkinje fibers constitute the most sensitive in vitro model for detecting drug-induced APD prolongation and proarrhythmogenic effects compared to other common laboratory species.

Cite This Study

Lu et al. (2001) studied this question.

synapsesocial.com/papers/6a75d6ce06e84d3015dd8a14 https://doi.org/10.1046/j.1540-8167.2001.00093.x

View Full Paper

Ask AI

Bookmark

Implication

Rabbit Purkinje fibers may be the preferred in vitro model for detecting drug-induced APD prolongation; leaves open translation to human proarrhythmia risk.

Species Plays an Important Role in Drug‐Induced Prolongation of Action Potential Duration and Early Afterdepolarizations in Isolated Purkinje Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Species Plays an Important Role in Drug‐Induced Prolongation of Action Potential Duration and Early Afterdepolarizations in Isolated Purkinje Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider