What question did this study set out to answer?

To evaluate and compare counterregulatory hormonal responses during severe hypoglycemia occurring under everyday conditions in patients with type 1 diabetes versus insulin-treated type 2 diabetes.

September 16, 2004Experimental and Clinical Endocrinology & Diabetes

Hormonal Counterregulation during Severe Hypoglycaemia under Everyday Conditions in Patients with Type 1 and Insulin-Treated Type 2 Diabetes Mellitus

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Authors

AHAndreas HolsteinKlinikum Lippe CHClaude HammerKlinikum Lippe APA. PlaschkeMedizinische Hochschule Hannover

Discussion

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Implication

Comparative study reveals similar hormonal counterregulatory failure during severe hypoglycemia in type 1 and advanced type 2 diabetes, indicating an equivalent risk of dangerous episodes.

Key Points

To evaluate and compare counterregulatory hormonal responses during severe hypoglycemia occurring under everyday conditions in patients with type 1 diabetes versus insulin-treated type 2 diabetes.
Assessed blood samples before and after emergency treatment in 28 consecutive patients with type 1 diabetes (mean age 54 ± 18 years; duration 27 ± 16 years) and 13 patients with insulin-treated type 2 diabetes (mean age 75 ± 13 years; duration 21 ± 6 years) experiencing severe hypoglycemia.
Measured counterregulatory hormones alongside clinical assessments of hypoglycemia awareness and the influence of beta-blocker therapy.
Plasma glucose increased from 30 ± 14 mg/dL before emergency treatment to 179 ± 82 mg/dL after treatment over an interval of 54 ± 26 minutes.
Glucagon responses were virtually absent and catecholamine responses were modest across both cohorts, showing no significant differences between groups other than higher human growth hormone levels in the younger type 1 patients.
Reduced awareness of hypoglycemia was present in 68% (19/28) of type 1 diabetic patients compared to 0% (0/13) of type 2 diabetic patients, and beta-blocker use did not affect counterregulation.

Cite This Study

Holstein et al. (2004) studied this question.

synapsesocial.com/papers/6a75d812030f9eaaaae695ca https://doi.org/10.1055/s-2004-821188

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Implication

Comparative study reveals similar hormonal counterregulatory failure during severe hypoglycemia in type 1 and advanced type 2 diabetes, indicating an equivalent risk of dangerous episodes.

Hormonal Counterregulation during Severe Hypoglycaemia under Everyday Conditions in Patients with Type 1 and Insulin-Treated Type 2 Diabetes Mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

Hormonal Counterregulation during Severe Hypoglycaemia under Everyday Conditions in Patients with Type 1 and Insulin-Treated Type 2 Diabetes Mellitus

Discussion

Member takes

Implication

Key Points

Cite This Study

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