Key result
Genetic inactivation of the BMP type IA receptor or BMP pathway inhibition resulted in the inhibition of aortic valve calcification in Klotho(-/-) mice and porcine cells.
Why the study?
Does BMP pathway inhibition prevent aortic valve calcification in preclinical models?
Does BMP pathway inhibition prevent aortic valve calcification in preclinical models?
BMP signaling is required for the development of aortic valve calcification, highlighting a potential mechanistic target for calcific aortic valve disease.
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BMP inhibition may attenuate aortic valve calcification; leaves open clinical translation pending human studies.
Gomez‐Stallons et al. (2016) studied Calcific aortic valve disease. BMP pathway inhibition or genetic inactivation of BMP type IA receptor was evaluated on Aortic valve calcification. Genetic inactivation of the BMP type IA receptor or BMP pathway inhibition resulted in the inhibition of aortic valve calcification in Klotho(-/-) mice and porcine cells.
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