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December 2, 2003BloodOpen Access

Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase

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Population

Human platelets

Design

Preclinical

Authors

SGStepan GambaryanVascular MedicineJGJörg GeigerHarvard UniversityUSUlrike R. SchwarzUniversity of Würzburg

Discussion

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Overview

May inform novel antiplatelet strategies; leaves open clinical translation pending human studies.

Structured PICO

P
Population
Human platelets
I
Intervention
cGMP analogs and cGK activators/inhibitors
O
Outcome
Platelet activation and inhibition, and ERK phosphorylationsurrogate

Extracellular cGMP analogs inhibit human platelet activation via a cGK-independent mechanism, confirming the inhibitory rather than activating role of cGK pathways in platelets.

Cite This Study

Gambaryan et al. (2003) studied this question.

synapsesocial.com/papers/6a75dde67d7eb453cc706ff7https://doi.org/10.1182/blood-2003-09-3349
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