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January 1, 2016Journal of Clinical and Preventive CardiologyOpen Access

Role of cyclic AMP and cyclic GMP as modulators of platelet cytosolic calcium

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Key result

Cyclic AMP and cyclic GMP modulate platelet cytosolic calcium levels, mediating the inhibitory effects of endogenous antagonists on platelet aggregation and function.

Population

Platelets

Design

Review

Authors

GRGunduH R RaoUniversity of Minnesota

Discussion

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Member takes

Overview

May guide novel antiplatelet drug targets; leaves open clinical efficacy in preventing vascular events.

Structured PICO

P
Population
Platelets
E
Exposure
Cyclic AMP and cyclic GMP modulators / anti-platelet agents
O
Outcome
Platelet cytosolic calcium levels and platelet aggregationsurrogate

Cyclic AMP and cyclic GMP modulate platelet cytosolic calcium, providing a mechanistic basis for developing novel antiplatelet drugs to prevent acute vascular events.

Cite This Study

GunduH R Rao (2016) conducted a review in Platelet aggregation. Cyclic AMP and cyclic GMP was evaluated. Cyclic AMP and cyclic GMP modulate platelet cytosolic calcium levels, mediating the inhibitory effects of endogenous antagonists on platelet aggregation and function.

synapsesocial.com/papers/6a20fa59b86afc18201823e4https://doi.org/10.4103/2250-3528.191101
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epinephrine potentiation of arachidonate‐induced aggregation of cyclooxygenase‐deficient platelets1981 · 53 citations
  2. 2Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model1986 · 228 citations