Cyclic 3′,5′‐adenosine Monophosphate in Human Blood Platelets Iv. Regulatory Role of Cyclic Amp in Platelet Function*

Edwin W. Salzman; Pamela C. Kensler; Linda Levine

doi:10.1111/j.1749-6632.1972.tb16287.x

October 1, 1972Annals of the New York Academy of Sciences

Cyclic 3′,5′‐adenosine Monophosphate in Human Blood Platelets Iv. Regulatory Role of Cyclic Amp in Platelet Function*

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Key Points

To review and assess whether cyclic adenosine 3',5' monophosphate (cAMP) regulates human blood platelet aggregation and activation.
Reviewed experimental literature linking cyclic nucleotide levels to platelet aggregation dynamics.
Incubated human blood platelets with radiolabeled cAMP and various pharmacological agents to measure changes in cyclic nucleotide levels and aggregation response.
Agents that elevate intracellular cyclic AMP levels consistently inhibit platelet aggregation.
Treatment with caffeine, collagen, thrombin, prostaglandins E1 and E2, and phosphodiesterase inhibitors increased platelet cyclic AMP and inhibited aggregation.

Structured PICO

P

Population

human blood platelets

I

Intervention

caffeine, colagen, thrombin, prostaglandins E1 and E2, and phosphodiesterase inhibitors

O

Outcome

platelet cAMP levels and platelet aggregationsurrogate

This preclinical study supports the hypothesis that increased intracellular cAMP levels in human platelets inhibit platelet aggregation.

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Implication

Supports cAMP-mediated platelet inhibition in animal models; leaves open translation to human antithrombotic strategies.

Abstract

Evidence which bears on the hypothesis that agents that increase platelet cyclic adenosine 3',5' monophosphate (cAMP) tend to inhibit platelet aggregation, whereas agents whose action is to induce or augment platelet aggregation are associated with a decrease in platelet content of this cyclic nucleotide is reviewed. Using radiolabeled cAMP in incubation with various agents, it was found that caffeine, colagen, thrombin, prostaglandins E1 and E2, and phosphodiesterase inhibitors are all agents that increase platelet cAMP and inhibit platelet aggregation.

Discussion

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Cite This Study

Salzman et al. (1972) studied this question.

synapsesocial.com/papers/6a8ba7bede5ec4e001e3cc36 https://doi.org/10.1111/j.1749-6632.1972.tb16287.x

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Cyclic 3′,5′‐adenosine Monophosphate in Human Blood Platelets Iv. Regulatory Role of Cyclic Amp in Platelet Function*

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Cyclic 3′,5′‐adenosine Monophosphate in Human Blood Platelets Iv. Regulatory Role of Cyclic Amp in Platelet Function*

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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