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October 1, 1972Annals of the New York Academy of Sciences

Cyclic 3′,5′‐adenosine Monophosphate in Human Blood Platelets Iv. Regulatory Role of Cyclic Amp in Platelet Function*

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Population

human blood platelets

Design

Preclinical

Authors

ESEdwin W. SalzmanCross-Cutting CardiologyPKPamela C. KenslerHarvard UniversityLLLinda LevineHarvard University

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Overview

Supports cAMP-mediated platelet inhibition in animal models; leaves open translation to human antithrombotic strategies.

Key Points

  • To review and assess whether cyclic adenosine 3',5' monophosphate (cAMP) regulates human blood platelet aggregation and activation.
  • Reviewed experimental literature linking cyclic nucleotide levels to platelet aggregation dynamics.
  • Incubated human blood platelets with radiolabeled cAMP and various pharmacological agents to measure changes in cyclic nucleotide levels and aggregation response.
  • Agents that elevate intracellular cyclic AMP levels consistently inhibit platelet aggregation.
  • Treatment with caffeine, collagen, thrombin, prostaglandins E1 and E2, and phosphodiesterase inhibitors increased platelet cyclic AMP and inhibited aggregation.

Structured PICO

P
Population
human blood platelets
I
Intervention
caffeine, colagen, thrombin, prostaglandins E1 and E2, and phosphodiesterase inhibitors
O
Outcome
platelet cAMP levels and platelet aggregationsurrogate

This preclinical study supports the hypothesis that increased intracellular cAMP levels in human platelets inhibit platelet aggregation.

Cite This Study

Salzman et al. (1972) studied this question.

synapsesocial.com/papers/6a8ba7bede5ec4e001e3cc36https://doi.org/10.1111/j.1749-6632.1972.tb16287.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle1968 · 1,452 citations
  2. 2Effect of prostaglandin E1 alone and in combination with theophylline or aspirin on collagen-induced platelet aggregation and on platelet nucleotides including adenosine 3′:5′-cyclic monophosphate1970 · 104 citations
  3. 3Inhibition and Reversal of Platelet Aggregation by Methyl Xanthines1967 · 63 citations