Population
Washed human platelets or platelet-rich plasma from freshly drawn blood of normal male subjects without drug…
Comparison
Human thrombin incubated at 37°C for up to 5… vs Platelets incubated at 4°C or 37°C without…
Design
Preclinical
Follow-up
5 minutes
Authors
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Challenges prevailing view that lowered cAMP mediates aggregation; animal data leave human relevance and clinical translation open.
Thrombin induces an increase, rather than a decrease, in intracellular cyclic AMP in human platelets, challenging the prevailing hypothesis that platelet aggregation is mediated by lowered cyclic AMP.
Droller et al. (1972) studied this question.
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