February 15, 1979FEBS Letters

Effects of adenosine 3′:5′‐monophosphate and platelet aggregation on thromboxane biosynthesis in human platelets

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Why the study?

Does elevation of cyclic AMP levels inhibit arachidonic acid release and thromboxane biosynthesis in human platelets?

Population

Human platelets

Design

Preclinical

Authors

JLJan LindgrenThe Wistar Institute HCHans‐Erik ClaessonMount Sinai Hospital HKH. KindahlSwedish University of Agricultural Sciences

Discussion

Member takes

Implication

Animal platelet data suggest aggregation-dependent TXB2 effects; leaves open translation to human platelet function or clinical antiplatelet strategies.

Structured PICO

Does elevation of cyclic AMP levels inhibit arachidonic acid release and thromboxane biosynthesis in human platelets?

Population

Human platelets

Intervention

Elevation of adenosine 3':5'-monophosphate (cyclic AMP) levels

Outcome

Arachidonic acid release and conversion of arachidonic acid to thromboxane B2 (TXB2)surrogate

The study clarifies that cyclic AMP inhibits thromboxane biosynthesis in human platelets indirectly by inhibiting platelet aggregation rather than directly inhibiting prostaglandin endoperoxide synthase.

Cite This Study

Lindgren et al. (1979) studied this question.

synapsesocial.com/papers/6a972249934adeec1901ff45 https://doi.org/10.1016/0014-5793(79)80192-1

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Implication

Animal platelet data suggest aggregation-dependent TXB2 effects; leaves open translation to human platelet function or clinical antiplatelet strategies.

Effects of adenosine 3′:5′‐monophosphate and platelet aggregation on thromboxane biosynthesis in human platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of adenosine 3′:5′‐monophosphate and platelet aggregation on thromboxane biosynthesis in human platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider