Population
Human platelet suspensions in vitro
Comparison
Cyclooxygenase or thromboxane synthetase… vs Absence of inhibitors
Design
Preclinical
Authors
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Animal platelet data show stimulus- and dose-dependent thromboxane independence; leaves open relevance to human aspirin efficacy and resistance.
The study demonstrates that platelet aggregation, secretion, and thromboxane production can occur independently depending on the specific stimulus and dose.
Best et al. (1980) studied this question.
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