Why the study?
Does antihypertensive therapy with ramipril and felodipine reduce QT dispersion and left ventricular mass index in untreated hypertensive subjects?
Population
124 untreated hypertensive subjects (100 in cross-sectional study, 24 in treatment study)
Comparison
Ramipril and felodipine for 6 months vs Baseline and post-treatment 2-week drug washout
Design
Cohort
Follow-up
6 months
Authors
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Reductions in QTc dispersion and LVMI were associated with ramipril-felodipine; leaves open effects on clinical outcomes in hypertension.
Does antihypertensive therapy with ramipril and felodipine reduce QT dispersion and left ventricular mass index in untreated hypertensive subjects?
Antihypertensive therapy with ramipril and felodipine significantly reduces both left ventricular mass index and QT dispersion in hypertensive patients.
Mayet et al. (1996) studied this question.
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