Key result
Higher LDL cholesterol levels were significantly associated with higher systolic blood pressure (regression coefficient 0.93 mmHg/mmol/L; 95% CI 0.54-1.31) in a large European population.
Observational (n=7,641)
Yes
Mean Difference: 0.93 (95% CI 0.54–1.31)
There is a small but statistically significant positive association between serum lipid levels and blood pressure in European patients with cardiovascular risk factors.
Should not change lipid or BP management; leaves open causal links for prospective trials.
OBJECTIVES: Several studies have suggested a positive association between serum lipid levels and blood pressure (BP). This study investigated this association in a large population from 12 European countries. METHODS: Data were taken from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (ClinicalTrials.gov identifier: NCT00882336). Associations between BP and lipid levels in patients free from cardiovascular disease and with at least one major cardiovascular disease risk factor (N = 7641) were assessed using linear regression analyses. RESULTS: Overall, 72.8 and 64.8% of patients had hypertension and dyslipidaemia, respectively; 47.0% had both conditions. Regression coefficients (95% confidence interval) for the associations of LDL cholesterol, non-HDL cholesterol, total cholesterol and apolipoprotein B levels with SBP, adjusted for age, sex and BMI, were 0.93 mmHg/mmol per l (0.54-1.31), 1.07 mmHg/mmol per l (0.73-1.40), 1.02 mmHg/mmol per l (0.69-1.35) and 4.94 mmHg/g per l (3.43-6.46), respectively. The corresponding values (95% confidence interval) for the associations with DBP were 0.96 mmHg/mmol per l (0.73-1.19), 0.95 mmHg/mmol per l (0.75-1.15), 0.87 mmHg/mmol per l (0.67-1.07) and 4.33 mmHg/g per l (3.42-5.23), respectively. Most of these associations remained significant whether patients were treated with statins or not. CONCLUSION: Small but statistically significant associations between lipid levels and BP were observed in a large, multinational European population. Further research is warranted to assess the causality of this association and its implications on the management of patients with both hypertension and dyslipidaemia.
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Borghi et al. (2016) conducted an observational in Cardiovascular disease risk factors (n=7,641). Serum lipid levels (LDL, non-HDL, total cholesterol, apolipoprotein B) was evaluated on Systolic blood pressure (SBP) (Regression coefficient 0.93 mmHg/mmol/L, 95% CI 0.54-1.31). Higher LDL cholesterol levels were significantly associated with higher systolic blood pressure (regression coefficient 0.93 mmHg/mmol/L; 95% CI 0.54-1.31) in a large European population.
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