Why the study?
Does hypopituitarism with conventional replacement therapy (without GH) worsen fasting and postprandial lipid profiles compared to matched normal controls?
Population
67 hypopituitary patients and 87 normal matched controls in the first study; 12 patients and 14 matched…
Comparison
Hypopituitarism with conventional replacement… vs Matched normal controls
Design
Case-control
Follow-up
24 hours
Authors
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Hypopituitary women on conventional therapy warrant lipid monitoring; hypothesis-generating for GH effects on vascular risk in prospective trials.
Does hypopituitarism with conventional replacement therapy (without GH) worsen fasting and postprandial lipid profiles compared to matched normal controls?
Hypopituitary women on conventional replacement therapy without growth hormone exhibit significant fasting and postprandial atherogenic lipid abnormalities, which may contribute to their increased vascular mortality.
Al-Shoumer et al. (1997) studied this question.
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