Key result
Complex multimorbidity was associated with an 83% higher risk of 11-year all-cause mortality compared to a relatively healthy pattern (HR 1.83) in community-dwelling adults.
Why the study?
The authors aimed to identify specific multimorbidity latent classes among multi-ethnic community-dwelling adults in Malaysia, explore associated risk factors, and examine relationships with 11-year all-cause mortality risk and health-related quality of life.
Population
18,101 community-dwelling adults aged 18-97 years in Malaysia
Comparison
Four multimorbidity latent classes identified from 13 chronic health conditions
Design
Prospective health and demographic surveillance system study
Follow-up
11 years
Authors
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Complex multimorbidity patterns were associated with highest mortality and lowest HRQoL; leaves open whether pattern-specific interventions improve outcomes in LMIC settings.
Cohort (n=18,101)
Hazard Ratio: 1.83 (95% CI 1.44–2.33)
p-value: p=<0.001
Complex multimorbidity is associated with significantly lower health-related quality of life and higher 11-year mortality risk compared to being relatively healthy.
Tan et al. (2025) conducted a cohort in Multimorbidity (n=18,101). Complex multimorbidity pattern vs. Relatively healthy pattern was evaluated on 11-year all-cause mortality (HR 1.83, 95% CI 1.44-2.33, p=<0.001). Complex multimorbidity was associated with an 83% higher risk of 11-year all-cause mortality compared to a relatively healthy pattern (HR 1.83) in community-dwelling adults.
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