Key result
A reduced left ventricular mass difference between end diastole and peak systole (<30.2 g) predicted major left coronary artery stenosis with 82.35% sensitivity and 70.37% specificity.
Why the study?
Does the difference in left ventricular mass at end diastole and peak systole measured by 2-dimensional echocardiography predict major stenosis of the left coronary artery?
Case-Control (n=79)
Does the difference in left ventricular mass at end diastole and peak systole measured by 2-dimensional echocardiography predict major stenosis of the left coronary artery?
Absolute Event Rate: 21.36% vs 40.12%
p-value: p=< .01
The difference in left ventricular mass between end diastole and peak systole measured by 2D echocardiography is a feasible and accurate non-invasive predictor of major left coronary artery stenosis.
May predict major left coronary stenosis via 2D echo LV mass difference; leaves open need for prospective validation before clinical use.
OBJECTIVES: To evaluate the feasibility of using the difference in left ventricular (LV) mass at end diastole and peak systole as determined by area-length calculation methods to detect major stenosis of the left coronary artery territory by 2-dimensional echocardiography. METHODS: The LV mass at end diastole, LV mass at peak systole, and LV mass difference between end diastole and peak systole were measured and compared between 39 healthy participants and 40 patients with coronary artery disease (CAD) referred for coronary angiography. The mass difference was compared to the mean percent stenosis diameter by linear correlation analysis, and its performance in discrimination between the patients with CAD and the healthy participants was analyzed. RESULTS: Compared to the healthy participants, the patients with CAD had significantly higher LV mass at peak systole (mean ± SD, 101.97 ± 30.34 versus 89.87 ± 28.71 g; P< .05) and a lower mass difference between end diastole and peak systole (21.36 ± 17.55 versus 40.12 ± 14.37 g; P < .01). The mass difference correlated significantly with the mean percent stenosis diameter (r = -0.71; P < .001) in patients with CAD . With the use of the mass difference as the criterion to distinguish patients with CAD from healthy participants, the area under the receiver operating characteristic curve was 0.81 (P < .05). The sensitivity, specificity, and accuracy for the prediction of major stenosis (>70%) of the left coronary artery were 82.35%, 70.37%, and 75% respectively for a mass difference of less than 30.2 g. CONCLUSIONS: The LV mass difference between end diastole and peak systole can effectively reflect the diameter changes of the left coronary artery, and a reduced mass difference is a sensitive and specific predictor of major stenosis of the left coronary artery territory.
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Zheng et al. (2012) conducted a case-control in Coronary artery disease (n=79). Reduced left ventricular mass difference between end diastole and peak systole vs. Healthy participants was evaluated on LV mass difference between end diastole and peak systole (p=< .01). A reduced left ventricular mass difference between end diastole and peak systole (<30.2 g) predicted major left coronary artery stenosis with 82.35% sensitivity and 70.37% specificity.
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