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The mouse pulmonary vein myocardium exhibits diverse spontaneous electrical activity that is enhanced by noradrenaline and reduced by acetylcholine.
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The mouse pulmonary vein myocardium exhibits diverse spontaneous electrical activity modulated by autonomic neurotransmitters, establishing it as a potential model for studying arrhythmogenesis.
We recorded the electrical activity from the myocardial layer of isolated mouse pulmonary veins with the glass microelectrode technique. Spontaneous electrical activity was observed in about half of the preparations, which appeared either as constant firing or as repetitive bursts. Noradrenaline enhanced, while acetylcholine reduced, automatic activity. The action potentials evoked in quiescent preparations showed a resting membrane potential less negative than the atria and an extremely rapid early repolarization followed by a late plateau. The present study revealed that the mouse pulmonary vein myocardium shows diverse electrical activity, which is influenced by autonomic neurotransmitters.
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Tsuneoka et al. (2012) studied Normal physiology (pulmonary vein automaticity) (n=144). Autonomic neurotransmitters (Noradrenaline, Acetylcholine) vs. Baseline was evaluated on Action potential parameters and spontaneous electrical activity. The mouse pulmonary vein myocardium exhibits diverse spontaneous electrical activity that is enhanced by noradrenaline and reduced by acetylcholine.
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