Why the study?
Does cirrhosis induced by bile duct ligation alter potassium currents in rat atrial and ventricular myocytes?
Population
Single myocytes from the atria and ventricles of sham-operated and bile duct-ligated cirrhotic adult rats
Comparison
Bile duct ligation (BDL) to induce cirrhosis vs Sham operation
Design
Preclinical
Authors
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Hypothesis-generating for QT prolongation in cirrhosis; requires human validation before any clinical consideration.
Does cirrhosis induced by bile duct ligation alter potassium currents in rat atrial and ventricular myocytes?
Cirrhosis reduces transient outward and delayed rectifier potassium currents in ventricular myocytes, providing a potential mechanism for Q-T prolongation in cirrhotic patients.
Ward et al. (1997) studied this question.
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