September 1, 1988British Journal of PharmacologyOpen Access

Contribution of β1‐ and β2‐adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (−)‐atenolol

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Population

Right atrial and left ventricular preparations from patients undergoing open heart surgery

Design

Preclinical

Authors

HLHorst LemoineHeinrich Heine University Düsseldorf HSHelmut SchönellHeinrich Heine University Düsseldorf AKAlberto J. KaumannElectrophysiology

Discussion

Member takes

Implication

Supports differential beta-adrenoceptor roles in animal hearts; leaves open confirmation in human myocardium.

Structured PICO

Population

Right atrial and left ventricular preparations from patients undergoing open heart surgery

Intervention

(-)-atenolol

Outcome

Positive inotropic effects of (-)-noradrenaline and (-)-adrenaline, beta-adrenoceptor binding, and adenylate cyclase stimulationsurrogate

In the human heart, beta 1-adrenoceptors primarily mediate the maximum positive inotropic effects of noradrenaline, while beta 2-adrenoceptors can mediate maximal effects of adrenaline in the atrium but not the ventricle.

Cite This Study

Lemoine et al. (1988) studied this question.

synapsesocial.com/papers/6a75e6cb1ce449dc42707388 https://doi.org/10.1111/j.1476-5381.1988.tb16548.x

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Contribution of β1‐ and β2‐adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (−)‐atenolol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contribution of β1‐ and β2‐adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (−)‐atenolol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider