Key result
An alpha-linolenic acid-enriched diet prevented isoproterenol-induced myocardial fibrosis and hypertrophy and preserved cardiac mechanical function in rats.
Why the study?
Does alpha-linolenic acid protect against cardiac injury and remodeling induced by beta-adrenergic overstimulation in rat models?
Population
Isolated rat cardiomyocytes (H9c2 cells) and in vivo rat models of isoproterenol-induced cardiac injury
Comparison
Alpha-linolenic acid in vitro and ALA-enriched… vs Control
Design
Preclinical
Follow-up
60 days (in vivo)
Authors
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No practice change from rat data; leaves open human translation of ALA cardioprotection.
Does alpha-linolenic acid protect against cardiac injury and remodeling induced by beta-adrenergic overstimulation in rat models?
Alpha-linolenic acid protects against beta-adrenergic overstimulation-induced cardiac fibrosis and hypertrophy via a caveolae-dependent Src-PI3K pathway in preclinical models.
Folino et al. (2015) studied Cardiac injury and remodelling induced by beta-adrenergic overstimulation. Alpha-linolenic acid (ALA) vs. Normal chow diet was evaluated on Myocardial fibrosis, hypertrophy, and cardiac mechanical function. An alpha-linolenic acid-enriched diet prevented isoproterenol-induced myocardial fibrosis and hypertrophy and preserved cardiac mechanical function in rats.
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