Key result
The virus derived from the infectious genome-length cDNA copy of the SAT2 vaccine strain (vSAT2) displayed excellent growth properties in cell culture, indicating potential for custom vaccine production.
The construction of an infectious genome-length cDNA copy of the SAT2 vaccine strain demonstrates potential for producing custom-made FMDV chimeras for vaccine production, though incompatibilities between certain viral components exist.
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May enable custom FMDV vaccine chimeras; leaves open in vivo efficacy and compatibility.
Rensburg et al. (2004) studied Foot-and-mouth disease virus (FMDV). Infectious genome-length cDNA copy of the SAT2 vaccine strain, ZIM/7/83 (vSAT2) vs. Various SAT2/A12 chimeras was evaluated on Growth properties in cell culture. The virus derived from the infectious genome-length cDNA copy of the SAT2 vaccine strain (vSAT2) displayed excellent growth properties in cell culture, indicating potential for custom vaccine production.
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