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May 1, 1998Journal of VirologyOpen Access

Foot-and-Mouth Disease Virus Virulent for Cattle Utilizes the Integrin α v β 3 as Its Receptor

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Population

Cell lines and Foot-and-Mouth Disease Virus variants

Comparison

Transfection with cDNAs encoding human integrin… vs Nontransfected cells or cells lacking heparan…

Design

Preclinical

Authors

SNSherry NeffUnited States Department of AgricultureDSDaniel Sá‐CarvalhoUniversidade Federal do Rio de JaneiroERElizabeth RiederNational Agricultural Statistics Service

Discussion

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Implication

Receptor adaptation may attenuate FMDV; leaves open integrin-targeted strategies for livestock control.

Structured PICO

P
Population
Cell lines (K562, normal CHO, HS-deficient CHO) and Foot-and-Mouth Disease Virus (FMDV) variants (type A12, type O1BFS, type O1Campos vCRM4, vCRM8)
I
Intervention
Transfection with cDNAs encoding human integrin alpha(v)beta3
C
Comparator
Nontransfected cells or cells lacking heparan sulfate (HS)
O
Outcome
Viral replication/infectionsurrogate

Virulent foot-and-mouth disease virus uses the integrin alpha(v)beta3 as its primary receptor, while cell culture adaptation shifts receptor usage to heparan sulfate, reducing virulence.

Cite This Study

Neff et al. (1998) studied this question.

synapsesocial.com/papers/6a1d75331c2cbcb15c5e57dahttps://doi.org/10.1128/jvi.72.5.3587-3594.1998
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RGD sequence of foot-and-mouth disease virus isessential for infecting cells via the natural receptor but can be bypassed by anantibody-dependent enhancement pathway.1994 · 255 citations
  2. 2Pathogenesis of wild-type and leaderless foot-and-mouth disease virus in cattle1996 · 117 citations
  3. 3Coxsackievirus B3 adapted to growth in RD cells binds to decay-accelerating factor (CD55)1995 · 276 citations
  4. 4VCAM-1 is a receptor for encephalomyocarditis virus on murine vascular endothelial cells1994 · 89 citations
  5. 5Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice1993 · 180 citations