November 1, 1997Journal of VirologyOpen Access

Arginine-glycine-aspartic acid-specific binding by foot-and-mouth disease viruses to the purified integrin alpha(v)beta3 in vitro

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Population

Purified integrin alpha(v)beta3 and foot-and-mouth disease viruses (FMDV) in vitro

Comparison

Short RGD-containing peptides vs Equivalent RGE peptide

Design

Preclinical

Authors

Discussion

Supports RGD-specific FMDV-integrin binding in vitro; hypothesis-generating for receptor-targeted strategies in animal models.

Population

Purified integrin alpha(v)beta3 and foot-and-mouth disease viruses (FMDV) in vitro

Intervention

Short RGD-containing peptides

Comparator

Equivalent RGE peptide

Outcome

Virus binding to purified alpha(v)beta3surrogate

FMDV binds to purified integrin alpha(v)beta3 in a highly sequence-specific, RGD-dependent manner in vitro.

Jackson et al. (1997) studied this question.

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