What does this research mean for the field?

The alpha V beta 3 vitronectin receptor functions as a cellular receptor for foot-and-mouth disease virus (FMDV), and antibodies targeting this receptor inhibit viral binding and infection. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1995Journal of VirologyOpen Access

Antibodies to the vitronectin receptor (integrin alpha V beta 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells

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Population

Cultured cells (BHK-21 and LLC-MK2 cells)

Comparison

Antibodies to the vitronectin receptor… vs Antibodies to the fibronectin receptor or to the…

Design

Preclinical

Authors

ABAnalía BerinsteinConsejo Nacional de Investigaciones Científicas y Técnicas MRMerja RoivainenNational Institutes of Health THT HoviInstitute for Molecular Medicine Finland

Discussion

Member takes

Implication

Identifies candidate receptor for FMDV antiviral strategies; leaves open in vivo relevance and therapeutic translation.

Structured PICO

Population

Cultured cells (BHK-21 and LLC-MK2 cells)

Intervention

Antibodies to the vitronectin receptor (integrin alpha V beta 3), including polyclonal anti-serum and monoclonal antibodies to alpha V and beta 3 subunits

Comparator

Antibodies to the fibronectin receptor (alpha 5 beta 1) or to the integrin (alpha V beta 5)

Outcome

FMDV binding and plaque formationsurrogate

The alpha V beta 3 vitronectin receptor functions as a cellular receptor for foot-and-mouth disease virus.

Cite This Study

Berinstein et al. (1995) studied this question.

synapsesocial.com/papers/6a1d75331c2cbcb15c5e57e1 https://doi.org/10.1128/jvi.69.4.2664-2666.1995

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Antibodies to the vitronectin receptor (integrin alpha V beta 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antibodies to the vitronectin receptor (integrin alpha V beta 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider