May 1, 2000Microbiology

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin α5β1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding

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Population

Purified preparations of human integrin α5β1 and foot-and-mouth disease virus (FMDV)

Design

Preclinical

Authors

TJTerry JacksonThe Pirbright Institute WBWendy BlakemoreThe Pirbright Institute JNJohn W. NewmanWestern Human Nutrition Research Center

Discussion

Member takes

Implication

Hypothesis-generating for FMDV receptor targeting; leaves open in vivo relevance and clinical translation.

Structured PICO

Population

Purified preparations of human integrin α5β1 and foot-and-mouth disease virus (FMDV)

Intervention

Solid-phase receptor-binding assay

Outcome

Binding of FMDV to integrin α5β1surrogate

This preclinical study demonstrates that foot-and-mouth disease virus can bind to the high-affinity conformation of human integrin α5β1, suggesting it may act as an important receptor in vivo.

Cite This Study

Jackson et al. (2000) studied this question.

synapsesocial.com/papers/6a82396947f72330e2ffb59f https://doi.org/10.1099/0022-1317-81-5-1383

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Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin α5β1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin α5β1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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