Key result
FMDV type A viruses utilized bovine αVβ3 and αVβ6 integrins with high efficiency, whereas type O viruses utilized αVβ6 and αVβ1 with higher efficiency than αVβ3 in vitro.
FMDV serotypes A and O exhibit different efficiencies in utilizing various bovine alpha(V) integrins for cell infection, which appears to be driven by the ligand-binding domains of the beta subunits.
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In vitro serotype-specific integrin preferences in FMDV are hypothesis-generating; leaves open in vivo relevance for pathogenesis and intervention.
Duque et al. (2003) studied Foot-and-Mouth Disease Virus (FMDV) infection (in vitro). Bovine αV integrins (αVβ1, αVβ3, αVβ5, αVβ6) was evaluated on Efficiency of integrin utilization by FMDV strains. FMDV type A viruses utilized bovine αVβ3 and αVβ6 integrins with high efficiency, whereas type O viruses utilized αVβ6 and αVβ1 with higher efficiency than αVβ3 in vitro.
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