August 26, 2004Journal of VirologyOpen Access

Interactions of Foot-and-Mouth Disease Virus with Soluble Bovine α V β 3 and α V β 6 Integrins

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Population

In vitro models including COS-1 cells, HEK 293A cells, BHK-21 cells, BHK3 cells, and Foot-and-Mouth Disease…

Design

Preclinical

Authors

Discussion

αVβ6 neutralizes FMDV in vitro unlike αVβ3; leaves open in vivo efficacy and therapeutic translation.

Population

In vitro models including COS-1 cells, HEK 293A cells, BHK-21 cells, BHK3 cells, and Foot-and-Mouth Disease Virus (FMDV) types A and O.

Intervention

Soluble bovine αVβ3 and αVβ6 integrins

Outcome

Viral replication (plaque reduction assays) and virus adsorption/binding

Soluble bovine αVβ6 integrin, but not αVβ3, binds to and neutralizes Foot-and-Mouth Disease Virus infectivity in vitro.

Duque et al. (2004) studied this question.

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